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Masters of Sex, protagonizada por Michael Sheen e Lizzy Caplan, é uma adaptação do livro Masters of Sex: The Life and Times of William Masters and Virginia Johnson, The Couple Who Taught America How to Love, de Thomas Maier.

A trama, ambientada nos anos 1960, explora as vidas de William Masters (Sheen) e Virginia Johnson (Caplan), pesquisadores pioneiros em sexualidade humana. Completam o elenco Margo Martindale, Beau Bridges, Caitlin Fitzgerald, Nicholas D'Agosto e Teddy Sears.

John Madden dirigiu o episódio-piloto e serve de produtor-executivo ao lado de Michelle Ashford, Carl Beverly, Sarah Timberman, Tammy Rosen, Judith Verno e Sheen.

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